Gene
pcna
- ID
- ZDB-GENE-000210-8
- Name
- proliferating cell nuclear antigen
- Symbol
- pcna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA polymerase processivity factor activity. Acts upstream of or within response to activity and response to bacterium. Located in nucleus. Is expressed in several structures, including anterior neural tube; head; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 155 figures from 93 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb16 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shin et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kh28 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
| kh29 | Allele with one deletion | Exon 1 | Frameshift | CRISPR | |
| kh30 | Allele with one deletion | Exon 1 | Inframe Deletion | CRISPR | |
| kh31 | Allele with one deletion | Exon 1 | Inframe Deletion | CRISPR | |
| kh32 | Allele with one insertion | Exon 1 | Inframe Deletion | CRISPR | |
| pd392Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa8962 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pcna | Thomas et al., 2014 | |
| CRISPR2-pcna | (2) | |
| CRISPR3-pcna | Kesavan et al., 2021 | |
| CRISPR4-pcna | (2) | |
| MO1-pcna | N/A | (5) |
| MO2-pcna | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia-telangiectasia-like disorder-2 | Alliance | ?Ataxia-telangiectasia-like disorder 2 | 615919 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR022659 | Proliferating cell nuclear antigen, PCNA, conserved site |
| Domain | IPR022648 | Proliferating cell nuclear antigen, PCNA, N-terminal |
| Domain | IPR022649 | Proliferating cell nuclear antigen, PCNA, C-terminal |
| Family | IPR000730 | Proliferating cell nuclear antigen, PCNA |
| Homologous_superfamily | IPR046938 | DNA clamp superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA clamp superfamily | Proliferating cell nuclear antigen, PCNA | Proliferating cell nuclear antigen, PCNA, conserved site | Proliferating cell nuclear antigen, PCNA, C-terminal | Proliferating cell nuclear antigen, PCNA, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PTP1 | InterPro | 260 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab20-pcna | polyclonal | Rabbit |
|
2 | |||
| Ab2-pcna | monoclonal | IgG2a , k | Mouse |
|
Sigma-Aldrich
Santa Cruz Biotechnology, Inc. Millipore Dako North America, Inc. Abcam plc Calbiochem Vector Laboratories Cell Signaling Technology, Inc. Life Technologies (Invitrogen) |
373 | |
| Ab4-pcna | polyclonal | Rabbit |
|
Abcam plc
|
5 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:RFP-pcna) |
|
| 1 | Boothe et al., 2017 | |
| Tg(pcna:GFP) |
|
| 1 | Xu et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-139N6 | ZFIN Curated Data | |
| Encodes | EST | cb16 | Thisse et al., 2001 | |
| Encodes | EST | fa28e03 | ||
| Encodes | EST | fb36g03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56705 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77707 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131404 (1) | 1492 nt | ||
| Genomic | GenBank:BX001050 (1) | 175495 nt | ||
| Polypeptide | UniProtKB:Q9PTP1 (1) | 260 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Cheng, X., Ju, J., Huang, W., Duan, Z., Han, Y. (2024) cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish. Journal of cardiovascular development and disease. 11(11):
- Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y. (2024) Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish. International Journal of Molecular Sciences. 25(23):
- Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Olson, H.M., Maxfield, A., Calistri, N.L., Heiser, L.M., Qian, W., Knaut, H., Nechiporuk, A.V. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development (Cambridge, England). 151(1):
- Zhu, M., Li, Y., Shen, Q., Gong, Z., Liu, D. (2024) Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade. Disease models & mechanisms. 17(10):
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Becker, C.J., Cigliola, V., Gillotay, P., Rich, A., De Simone, A., Han, Y., Di Talia, S., Poss, K.D. (2023) In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Development (Cambridge, England). 150(24):
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