Gene
robo1
- ID
- ZDB-GENE-000209-3
- Name
- roundabout, axon guidance receptor, homolog 1 (Drosophila)
- Symbol
- robo1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable axon guidance receptor activity. Acts upstream of or within axon guidance and endocardial progenitor cell migration to the midline involved in heart field formation. Predicted to be located in plasma membrane. Is expressed in basal plate midbrain region; epidermis; nervous system; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; combined or isolated pituitary hormone deficiency 8; congenital nystagmus; multiple myeloma; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d100 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012771Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019385Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019386Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019387Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019388Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2786 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7411 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa8915 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11384 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12940 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 19
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-robo1 | Jayadev et al., 2022 | |
| CRISPR2-robo1 | Jayadev et al., 2022 | |
| CRISPR3-robo1 | Jayadev et al., 2022 | |
| CRISPR4-robo1 | Jayadev et al., 2022 | |
| MO1-robo1 | N/A | (3) |
| MO2-robo1 | N/A | (2) |
| TALEN1-robo1 | Mahabaleshwar et al., 2022 |
1 - 7 of 7
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive congenital nystagmus | Alliance | ?Nystagmus 8, congenital, autosomal recessive | 257400 |
| combined or isolated pituitary hormone deficiency 8 | Alliance | Pituitary hormone deficiency, combined or isolated, 8 | 620303 |
| Neurooculorenal syndrome | 620305 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Neural and epithelial cell adhesion domain-containing protein | Roundabout homologue 1, immunoglobulin-like domain 3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z4C2 | InterPro | 1647 | |||||||||||
| UniProtKB:A0A8M1P7C2 | InterPro | 1646 | |||||||||||
| UniProtKB:A0A8M6Z9L1 | InterPro | 1650 | |||||||||||
| UniProtKB:A0A8M6Z2U1 | InterPro | 1679 | |||||||||||
| UniProtKB:A0A8M6Z2U5 | InterPro | 1649 |
1 - 5 of 20 Show all
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31J4 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d100 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:195108 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309824 (1) | 6871 nt | ||
| Genomic | GenBank:CR626875 (2) | 212742 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z9Z4 (2) | 1705 aa |
- Zhou, L., Zhang, W., Xiang, Y., Qian, Z., Zhou, J., Ni, L., Feng, Y., Gao, B. (2023) The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC. Open life sciences. 18:2022053320220533
- Jayadev, R., Morais, M.R.P.T., Ellingford, J.M., Srinivasan, S., Naylor, R.W., Lawless, C., Li, A.S., Ingham, J.F., Hastie, E., Chi, Q., Fresquet, M., Koudis, N.M., Thomas, H.B., O'Keefe, R.T., Williams, E., Adamson, A., Stuart, H.M., Banka, S., Smedley, D., Genomics England Research Consortium, Sherwood, D.R., Lennon, R. (2022) A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. Science advances. 8:eabn2265
- Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464
- Chen, K., Fan, Y., Gu, J., Han, Z., Zeng, H., Mao, C., Wang, C. (2020) In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether. Drug design, development and therapy. 14:3069-3078
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Lu, T., Zhang, T., Wang, C., Yang, N., Pan, Y.H., Dang, S., Zhang, W. (2019) Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation. Biochemical and Biophysical Research Communications. 521(4):907-913
- Chen, K., Wang, C., Fan, Y., Gu, J., Han, Z., Wang, Y., Gao, L., Zeng, H. (2018) Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity. Experimental and Therapeutic Medicine. 16:4562-4568
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 10 of 30
Show