Gene
anos1a
- ID
- ZDB-GENE-000201-9
- Name
- anosmin 1a
- Symbol
- anos1a Nomenclature History
- Previous Names
-
- anosmin-1a (1)
- kal1a
- kal1.1
- wu:fl91z45
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable peptidase inhibitor activity and serine-type endopeptidase activity. Acts upstream of or within neuron differentiation; olfactory bulb development; and posterior lateral line development. Predicted to be located in extracellular region. Predicted to be active in cell surface. Is expressed in several structures, including digestive system; nervous system; neural tube; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73357 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 1 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1) | 308700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR008197 | WAP-type 'four-disulfide core' domain |
| Domain | IPR040957 | Anosmin-1, cysteine rich domain |
| Family | IPR042447 | Anosmin-1 |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036645 | Elafin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Anosmin-1 | Anosmin-1, cysteine rich domain | Elafin-like superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | WAP-type 'four-disulfide core' domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9IAR4 | InterPro | 652 | |||||||
| UniProtKB:A0A8M1PBX0 | InterPro | 652 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anos1a-201
(1)
|
Ensembl | 2,392 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-anos1a | polyclonal | Rabbit |
|
3 | |||
| Ab2-anos1a | polyclonal | Rabbit |
|
3 |
Plasmids
No data available