FIGURE

Figure 7

ID

ZDB-FIG-250304-14

Publication

Sertori et al., 2025 - Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia

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Figure 7

Impact of Chtf18 variants on HSPC migration.(A) Gene Set Enrichment analysis (EnrichGo) of the highly variable expressed genes between Chtf18 WT and mut CLP cluster (upper panel). (Bottom Panel) Volcano plot of the top differentially expressed genes between Chtf18 WT and mut CLP cluster. (B) The impact of Ctf18 loss on the localization of HSPC in zebrafish embryos was examined by MO knockdown of chtf18 (chtf18e6), following which the location of HSPC in the caudal hematopoietic tissue was assessed by WISH using a probe for runx1. Statistical significance was assessed by Fisher’s Exact Test, with the p=6.8x10-7 for Con. vs Ctfe6.

Expression Data

Gene:	runx1
Fish:	TL TL + MO1-chtf18
Knockdown Reagent:	MO1-chtf18
Anatomical Term:	hematopoietic stem cell
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO1-chtf18
Knockdown Reagent:	MO1-chtf18
Observed In:	hematopoietic stem cell
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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