FIGURE

Fig. 3

ID

ZDB-FIG-241204-3

Publication

Burrows et al., 2024 - RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Embryonic and adult C9orf72-ALS/FTD zebrafish lines produce multiple RAN-translated DPR species. V5-DPRs and poly-repeats species GP, GR, and PR in (A) sense (S5) and (B) antisense (AS1) 5 days postfertilization embryonic lysates compared to non-transgenic (NTG) and 2mer (Ctrl). V5-DPR species detected in 12 month (C) brain and (D) muscle lysates of sense (S5) and antisense (AS1) C9orf72-ALS/FTD zebrafish. Arrows indicate DPR bands which are proposed to be driven by RAN-translation. Asterisks indicate non-specific antibody binding. ALS = amyotrophic lateral sclerosis; FTD = frontotemporal dementia; DPR = dipeptide repeat; RAN = repeat-associated non-AUG.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ann. Neurol.