FIGURE

Fig. 3

ID

ZDB-FIG-241002-12

Publication

Giong et al., 2024 - Tau accumulation is cleared by the induced expression of VCP via autophagy

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Fig. 3

VCP induction correlates with Tau overexpression and clearance. a Top ten GO of DEGs from the comparative transcriptomic analysis of the Tau tg vs the Ctrl line. b A volcano plot of autophagy-related DEGs, identifying vcp and eif4ebp1 as the most significant DEGs with highest p value or fold change. c mRNA expression profile of vcp from 1 to 5 dpf by quantitative RT-PCR. d Western blots with antibodies against Vcp, total Tau (T46), pTau (AT8) and autophagy markers (LC3, p62) for the Ctrl and Tau Tg lines from 1 to 5 dpf. e Whole-mount co-staining of anti-HuC antibody and vcp mRNA fluorescence in situ hybridization (FISH). f Enlarged view of yellow boxes in (e). Student t test, **p < 0.01; ***p < 0.005, Scale bar (in e and f) = 50 µm

Expression Data

Gene:	vcp
Antibody:	Ab4-vcp
Fish:	WT krb5Tg/krb5Tg
Anatomical Terms:	brain spinal cord whole organism
Stage Range:	Prim-5 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	krb5Tg/krb5Tg
Observed In:	brain spinal cord whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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