FIGURE

Figure 7

ID

ZDB-FIG-240229-196

Publication

Zhang et al., 2024 - Nomo1 deficiency causes autism-like behavior in zebrafish

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Figure 7

Melatonin treatment rescues overactive locomotor behavior and repetitive stereotypic behavior in nomo1^−/−.

(A) Statistical analysis of the SRM/MRM data. The vertical axis denotes the normalized levels of neurotransmitters and metabolites (biological replicates, N = 3). (B) Statistical analysis of the HPLC data. The vertical axis denotes the levels of 4 neurotransmitters and metabolites in zebrafish brain (biological replicates, N = 8). (C) Melatonin levels of nomo1^−/− and nomo1^+/+ (biological replicates, N = 3). (D–F) Locomotor activity (D) (biological replicates, N = 24), shoaling behavior (E) (biological replicates, N = 24), and three kinds of repetitive behaviors (F) (biological replicates, N = 24) of WT, mutant and MT treatment zebrafish. NT was short for no treatment. Data are analyzed using unpaired t test and presented as the means ± SEM, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 and ^****P < 0.0001. Source data are available online for this figure.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nomo^{zf3952/zf3952}
Condition:	chemical treatment by environment: melatonin
Observed In:	brain L-dopa brain melatonin brain serotonin locomotory behavior social behavior
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

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