FIGURE

Fig. 3.

ID

ZDB-FIG-231002-107

Publication

Leid et al., 2023 - Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

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Fig. 3.

cora^stl325 embryos have craniofacial deformities and neuroanatomical defects. (A) Head morphology of control and cora^stl325 embryos at 96 hpf. (B) Head-to-body and head-to-eye ratios. Control (n=13), cora^stl325 (n=9). (C) Alcian Blue staining of control and cora^stl325 embryos at 96 hpf (left), with quantification of major jaw elements (right). EP, Ethmoid plate; MC, Meckel's Cartilage; T, Trabeculae. n=9 per experimental group. (D) H&E staining of the jaw of control and cora^stl325 embryos at 96 hpf. (E) Fluorescence microscopy images of Tg(crestin::GFP) and Tg(sox10::RFP) control and cora^stl325 embryos. (F) X-ray microscopy-generated images of 96 hpf embryos (left) and quantification of tissue volume (right). Br, brain Control (n=4), cora^stl325 (n=4).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	taf5^{stl325/stl325}
Observed In:	brain ethmoid cartilage Meckel's cartilage trabecula cranii
Stage:	Day 4

Phenotype Detail

Acknowledgments

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