FIGURE

Fig. 6.

ID
ZDB-FIG-230609-41
Publication
Lelièvre et al., 2023 - Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish
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Fig. 6.

Both long and short Endoglin isoforms rescue eng−/− heart failure. (A) PCR genotyping example of established fli1a:engLong and fli1a:engshort transgenic lines. Amplicon size difference is due to exon 13 inclusion in endoglin short coding transcript. (B) Mutant phenotype frequency in clutches from, eng+/−, Tg(fli1a:engLong) and eng+/−, Tg(fli1a:engshort) with eng+/− fish at 3 dpf. Total number of mutants over total number of fish analyzed is indicated above bars. (C) Genotype distribution frequency and associated survival in 5-month-old fish from crosses between eng+/− and eng+/−, Tg(fli1a:engLong) or eng+/−, Tg(fli1a:engshort). Left column shows even transgene distribution among the different genotypes. Fish numbers are indicated above bars. Right column shows Kaplan–Meier representation of survival according to genotype and transgenic status. −/− versus −/−, Tg(fli1a:engLong) or Tg(fli1a:engshort), ***P<0.0001 [log-rank (Mantel–Cox) test].
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish: (all 6)
Observed In:
Stage Range: Days 45-89 to Adult

Phenotype Detail
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