FIGURE

FIGURE 7

ID

ZDB-FIG-210611-55

Publication

Morris et al., 2021 - A Novel Lysolecithin Model for Visualizing Damage in vivo in the Larval Zebrafish Spinal Cord

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FIGURE 7

Oligodendrocyte cytoskeletal components dynamically change following exposure to lysolecithin. All images are lateral views of the spinal cord with anterior to the left and dorsal to the top. (A)In vivo imaging of Tg(sox10:Gal4; UAS:Lifeact-gfp) larvae at 6 dpf. Arrowheads denote the actin in sheath formation. (B) Following injection of lysolecithin into a 6 dpf Tg(sox10:Gal4; UAS-Lifeact-gfp) zebrafish, in vivo time-lapse imaging reveals that GFP⁺ F-actin dynamically changes from a sheath-like arrangement (2 hpi) to forming ovoid-like structures (8 hpi). Arrowheads identify the GFP⁺ F-actin changes in a sox10⁺ cell. Scale bars, 25 μm.

Expression Data

Gene:	GFP
Fish:	km6Tg/km6Tg; mu271Tg/mu271Tg
Condition:	chemical treatment by injection: 1-O-palmitoyl-sn-glycero-3-phosphocholine
Anatomical Term:	spinal cord oligodendrocyte
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	km6Tg/km6Tg; mu271Tg/mu271Tg
Condition:	chemical treatment by injection: 1-O-palmitoyl-sn-glycero-3-phosphocholine
Observed In:	oligodendrocyte actin filament organization
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol