FIGURE

Figure 7

ID
ZDB-FIG-210528-11
Publication
Wang et al., 2021 - Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture
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Figure 7

Inhibition of ADAMTS-5 causes intracranial hemorrhage in zebrafish. (A) Zebrafish embryos treated with DMSO (control, CTRL group), and intracranial hemorrhage in embryos treated with 0.5 μg/mL of ADAMTS-5 inhibitor (ATS5-in). The black arrow indicates the bleeding site. (B) O-Dianisidine staining confirming intracranial hemorrhage at 72 hpf. (C) Confocal microscopy showing cerebral blood vessel leakage of the Tg (flk: EGFP; gata1: DsRed) embryo. (D) Incidence rates of intracranial hemorrhage of the control group (CTRL) and ADAMTS-5 inhibitor treatment group (ATS5-in) at 0.25 μg/mL and 0.5 μg/mL. Scale bar: 50 μm. **P<0.01.
Expression Data
Genes:
Fish:
Condition:
Anatomical Term:
Stage: Protruding-mouth

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Condition:
Observed In:
Stage: Protruding-mouth

Phenotype Detail
Acknowledgments
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