FIGURE

Figure 2

ID

ZDB-FIG-210322-2

Publication

Kim et al., 2021 - Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model

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Figure 2

Tacrine and duloxetine show no effect on oligodendrocyte differentiation during development. All images are lateral views of the spinal cord of Tg(mbpa:egfp;olig2:dsred), anterior to the left and dorsal to the top. Larvae were exposed to 0.2% DMSO (a), 250 nM tacrine (b), and 10 μM duloxetine (c) during dpf 2 to 5. Arrowheads indicate olig2 + dorsally migrated oligodendrocytes. (d) Quantification of the number of olig2 + dorsally migrated oligodendrocytes per 3-somite area. Control: 22.16 ± 2.64, 250 nM tacrine: 21.5 ± 1.64, 10 μM duloxetine: 20.16 ± 2.79. (e) Quantification of the number of MBP + mature oligodendrocytes per 3-somite area. Control: 13 ± 3.41, 250 nM tacrine: 11.8 ± 2.99, 10 μM duloxetine: 12.17 ± 2.64. n = 6 per group; n.s., not significant. Scale bar, 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	km5Tg/km5Tg; nkuasgfp1aTg/nkuasgfp1aTg; vu19Tg/vu19Tg
Conditions:	chemical treatment by environment: duloxetine chemical treatment by environment: tacrine
Observed In:	spinal cord oligodendrocyte differentiation
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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