FIGURE

Fig 12

ID

ZDB-FIG-191230-1554

Publication

Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway

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Fig 12

Liability-threshold model and tuned circuitry model for <italic>mef2ca</italic> heritable variable penetrance.

(A) The liability-threshold model illustrates the inheritance of ectopic bone penetrance in mef2ca mutants following selective breeding. The difference between the mean of the population and the threshold is defined as x. x_F0-op = 0.468, x_high-op = -1.080 and x_low-op = 1.918. (B) The multiple threshold model illustrates how the same modifiers can shape liability and penetrance of different mef2ca mutant phenotypes to different extents. x_{high-jaw joint} = -4, x_{low-jaw joint} = -.806 x_high-op = -1.08 x_low-op = 1.476. (C) Model for how tuning down of Jag/N-driven transcription of her6 can result in mef2ca low penetrance. This genetic circuitry downstream of mef2ca is consistent with mutant, genetic epistasis, and gene expression analyses in this study.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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