FIGURE

Fig. 4

ID

ZDB-FIG-190618-65

Publication

James et al., 2019 - Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism

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Fig. 4

DT transit time of fluorescent beads is prolonged in shank3abΔC^+/− mutants compared to WT larvae. a Regions of the DT analyzed for fluorescent bead occupancy are indicated on a 7-day-old zebrafish larva. Beads were tracked as they passed through five key regions: PH (pharynx), IB (intestinal bulb), UI (upper intestine), LI (lower intestine), and EX (expelled). The swim bladder (SB) is labeled for reference. b Images of a representative WT fish at 3, 6, 12, and 24 h post-feed. Beads appear white and can be seen throughout the DT and collecting near the anus post-expulsion. c Images of a representative shank3abΔC ^+/− larva at 3, 6, 12, and 24 h post-feed. d Graph of bead distribution per time point for WT fish. Each point represents the average +/− standard error of the percentage of total beads held by each region (PH, IB, UI, LI, or EXP) over time (n = 13). e Graph of shank3abΔC ^+/− mutant average +/− standard error bead distribution over time (n = 15)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	shank3a^umi101/+; shank3b^umi102/+ (AB)
Observed In:	intestinal bulb intestine smooth muscle contraction intestinal motility
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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