FIGURE

Fig. 8

ID

ZDB-FIG-180502-30

Publication

Chou et al., 2017 - A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish

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Fig. 8

Tmc2a coordinates with Tmc2b to enable mechanotransduction in lateral line hair cells. a Stimulus-evoked microphonic potentials measured from posterior neuromasts with A–P-oriented hair cells from 6-dpf zebrafish larvae. The response in tmc2a ^−/− /tmc2b ^−/− is absent, bottom trace. b Graph of mean microphonic potentials from posterior neuromasts with hair cells with A–P orientations (n = 6). **Mann–Whitney test P = 0.0043. c, d Confocal images of hair cells from LII.1 and IO4 neuromasts of tmc2a ^+/− /tmc2b ^+/− or tmc2a ^−/− /tmc2b ^−/− animals labeled with FM1-43FX (red) and phalloidin (cyan). No dye was observed in LII.1 or IO4 of tmc2a ^−/− /tmc2b ^−/− animals. Scale bar = 6 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tmc2b^cwr9/+; tmc2a^cwr10/+ tmc2b^cwr9/cwr9; tmc2a^cwr10/cwr10
Observed In:	infraorbital lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound posterior lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound
Stage:	Day 6

Phenotype Detail

Acknowledgments

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