FIGURE

Fig. 4

ID

ZDB-FIG-171227-37

Publication

Mei et al., 2014 - Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms

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Fig. 4

Normal Pk localization in bbs7 knockown embryos and normal BBsome formation in Pk2^−/− mouse tissues. (A) and (B) GFP-Pk localization in the developing neural tube at 24 hpf. (A) GFP-Pk localization. (B) GFP-Pk localization with bbs7 MO injected. Asterisks mark cells with anterior GFP-Pk puncta. Anterior of the embryo is oriented to the top. Scale bars are 30 μm. (C) Quantification of percentage of GFP-positive cells with anterior puncta. For control, n=53; bbs7 MO, n=41. (D) Immunoprecipitation analysis demonstrates BBSome formation in Pk2 mutants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 392(2), Mei, X., Westfall, T.A., Zhang, Q., Sheffield, V.C., Bassuk, A.G., Slusarski, D.C., Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms, 245-55, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.