FIGURE

Fig. 3

ID

ZDB-FIG-170505-32

Publication

Saitoh et al., 2017 - Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells

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Fig. 3

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Fig. 3

Rab5 plays a crucial role in apical extrusion of v-Src–expressing cells in the EVL of zebrafish embryos. (A) Confocal images of a Rab5-YFP–expressing zebrafish embryo (at 10–11 h postfertilization, 3 h after tamoxifen treatment) with RFP–v-Src in a mosaic manner. (Scale bar, 20 μm.) (B and C) Effect of expression of Rab5DN on apical extrusion of v-Src–expressing cells. Embryos were injected with the GFP–v-Src–expressing vector with or without the Rab5DN cassette. Representative images are shown in B. Arrows indicate apically extruded v-Src–expressing cells. (Scale bar, 10 μm.) (C) Quantification of apical extrusion of v-Src–expressing cells. Data are mean ± SD from four independent experiments. *P < 0.05; n = 490 and 364 cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA