FIGURE

Fig. 3

ID

ZDB-FIG-170428-28

Publication

El-Rass et al., 2017 - Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly.

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Fig. 3

Pdgfra homozygous mutants exhibit abnormal cardiac phenotypes. An incross of the pdgfra gene-trapped strain carrying a Tg(cmlc2:EGFP) transgene was used to investigate the cardiac phenotype. (A) At 48 hpf, mild and severe −/− mutants present with abnormal cardiac looping; severe −/− embryos also develop an enlarged atrium and pericardial edema. (B) At 96 hpf, the hearts of mild −/− mutants remain incompletely looped, while severe −/− mutants present with collapsed chambers and pericardial edema. Arrows pointing at ventricle (V) and atrium (A). The fish cranium is on the left. Scale bar: 100 μm.

Expression Data

Gene:	EGFP
Fish:	twu34Tg pdgfra^{smh1300Gt/smh1300Gt}; twu34Tg
Anatomical Term:	cardiac muscle cell
Stage Range:	Long-pec to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdgfra^{smh1300Gt/smh1300Gt}; twu34Tg
Observed In:	atrium heart heart looping pericardium
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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