FIGURE

Fig. S9

ID

ZDB-FIG-170220-46

Publication

Wild et al., 2017 - Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization

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Fig. S9

Ectopic venous sprouting requires hemodynamic factors and Akt

(a-d) Loss of hemodynamics rescues hyper-branching in flt1^ka601 mutants. (a) WT treated with DMSO; (b) flt1^ka601 treated with DMSO; (c) inhibition of cardiac activity with 2,3-Butanedione monoxime (BDM) in flt1^ka601 (d) flt1^ka601 exposed to 2.5X tricaine. mean ± s.e.m, 20-25 embryos/group, Mann Whitney U test. (e) Quantification of a-d. Note that inhibiting blood flow with BDM or tricaine inhibited ectopic branching. (f) Vascular branching after blockade of PI3 kinase with wortmannin. mean ± s.e.m, 3 experiments, 15-18 embryos/group, Mann Whitney U test. Scale bar, 20μm in a-d.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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