FIGURE

Fig. 6

ID

ZDB-FIG-150528-6

Publication

Liu et al., 2015 - DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish

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Fig. 6

WISH assays of cmyb in cebpa null mutants and siblings with or without dnmt1 mutation. (A) WISH assay of cmyb in embryos without cebpa and dnmt1 homozygote mutation. (B) WISH assay of cmyb in embryos only with dnmt1 homozygote mutation. Note that cmyb was markedly decreased. (C) WISH assay of cmyb in embryos only with cebpa homozygote mutation. (D) WISH assay of cmyb in embryos both with cebpa and dnmt1 homozygote mutation. Note that cmyb was comparable with embryos without dnmt1 homozygote mutation. (A′-D′) Magnified images of the boxed regions in A to D. Red arrows indicate cmyb-positive HSPCs in the CHT.

Expression Data

Gene:	myb
Fish:	TU cebpa^rj31/rj31 dnmt1^rj794/rj794 (TU) dnmt1^rj794/rj794; cebpa^rj31/rj31
Anatomical Terms:	caudal hematopoietic tissue hematopoietic stem cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnmt1^rj794/rj794 (TU) dnmt1^rj794/rj794; cebpa^rj31/rj31
Observed In:	caudal hematopoietic tissue definitive hemopoiesis hematopoietic stem cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Hematol. Oncol.