FIGURE

Fig. 4

ID

ZDB-FIG-120316-105

Publication

Kirchmaier et al., 2012 - The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development

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Fig. 4

Myotendinous junctions are altered in popdc2 morphants. Confocal imaging of the trunk musculature of 24 hpf embryos in a lateral view, anterior to the left. (A,B) FAK and (C,D) vinculin expression in (A,C) MO-control and (B,D) MO1-popdc2 injected embryos. In the popdc2 morphants the shape of the myotomal boundaries is disturbed and the expression domains of FAK and vinculin are discontinuous (arrow heads). (A′–D′) Beta-catenin staining. (A′′–D′′) Merge of panel (A–D) and (A′–D′). Scale bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-popdc2
Knockdown Reagent:	MO1-popdc2
Observed In:	myotome myotome muscle tendon junction
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 363(2), Kirchmaier, B.C., Poon, K.L., Schwerte, T., Huisken, J., Winkler, C., Jungblut, B., Stainier, D.Y., and Brand, T., The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development, 438-450, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.