FIGURE

Fig. 7

ID

ZDB-FIG-110712-77

Publication

Gregory-Evans et al., 2011 - Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma

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Fig. 7

Effect of caspase inhibition on survival and optic fissure closure. A: Mean survival of gup mutant embryos with no treatment or with either diferuloylmethane, zVAD-fmk or control inhibitor zFA-fmk. n=30 for each group, mean±SEM (*p<0.001). B: Wildtype (wt) larval phenotype at 8 dpf. C: Phenotype of gup mutants treated with 5 μM diferuloylmethane. D: Phenotype of gup mutant embryos treated with 300 μM zVAD-fmk. E: Phenotype of gup mutants treated with 300 μM zFA-fmk. Arrows indicate the position of the coloboma. Size bar in left panels=200 μm; size bar in right panels=500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lamb1a^m189/m189
Conditions:	chemical treatment by environment: curcumin chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F
Observed In:	whole organism
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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