FIGURE

Fig. S5

ID

ZDB-FIG-100707-44

Publication

Rojas-Muñoz et al., 2009 - ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration

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Fig. S5

ErbB2 is translated upon amputation in the regeneration blastema. Antibodies anti-ErbB2 (green panels) and anti-Phospho Y (red panels) are colocalized in the blastema and the Neuromasts of regenerating larvae. Single confocal sections suggest that ErbB2 is mainly localized to the cellular membrane of blastema cells (paraxial plane). Larvae incubated in 5 μM LY294002 and 10 μM PD168393 exhibit a delay in the formation of the blastema (PD/LY) but ErbB2 is still detected at the amputation plane (white arrowheads). Anterior to the left, dorsal up and 6dpf / 1dpi larvae in all panels. Scale bar 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 327(1), Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C., ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration, 177-190, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.