FIGURE

Fig. 1

ID

ZDB-FIG-100628-13

Publication

Reynolds et al., 2010 - VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish

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Fig. 1

Activity of mouse Looptail VANGL1 mutant RNAs in zebrafish lacking tri. Panels A–E show lateral views of zebrafish at 2 days post fertilization. In Panel A, an uninjected wild-type fish is shown. In Panel B, a fish injected with tri-MO alone show a marked shortening of the trunk. In Panel C, VANGL1 RNA partially rescued the trunk phenotype induced by co-injection of tri-MO. Co-injection of VANGL1^D259E (Panel D) or VANGL1^S467N (Panel E) with tri-MO did not rescue the reduced body length phenotype induced by tri-MO.

Expression Data

Gene:	myod1
Fish:	WT WT + MO1-vangl2
Knockdown Reagent:	MO1-vangl2
Anatomical Term:	somite
Stage Range:	5-9 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-vangl2
Knockdown Reagent:	MO1-vangl2
Observed In:	trunk whole organism anterior-posterior axis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 127(7-8), Reynolds, A., McDearmid, J.R., Lachance, S., Marco, P.D., Merello, E., Capra, V., Gros, P., Drapeau, P., and Kibar, Z., VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish, 385-392, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.