MOD landing pages at the Alliance portal. A common look and feel that allows community-specific content.

Paralog table for C. elegans hlh-25. The table presents a ranking of paralogs for the hlh-25 gene, based on a weighted scoring algorithm that incorporates sequence conservation metrics. It lists the gene symbols, provides the alignment length in amino acids, and quantifies the similarity and identity percentages of genes paralogous to hlh-25. The methodology count, indicating the number of algorithms supporting the paralogous relationship, is also included. In this ranking, hlh-27 is identified as the primary paralog due to its high similarity and identity scores, despite being recognized by fewer methods than hlh-28.

Sequence detail widget. Chosen views of a specific gene are readily available for copying as plain text or with highlights. 5′ region of the human PLAA gene.

Screenshot of results from the Alliance SequenceServer BLAST tool. The results have been enhanced relative to the default SequenceServer results page by the addition of links to Alliance JBrowse and to the corresponding gene page (in this case C. elegans abi-1) at the Alliance website for each BLAST hit.

Output of a BLAST search. After a user clicks on the JBrowse link for a BLAST hit, they are directed to the web service where they will see a track for the BLAST hit and how the hit aligns with other tracks.

AllianceMine example. Using a simple template, a disease ontology (DO) term, in this case “autism,” is chosen, and all genes associated with this DO term are returned in a downloadable table.

Alliance pathway viewer. The pathway widget displays gene products (rectangles with gene names) and chemicals (rectangles with chemical abbreviations) and the flow of information and material between them (relations). These relations, shown in legend, indicate direct or indirect regulation that can be positive, negative, or of unknown effect direction. For metabolites that mediate the information flow between gene products, distinct shading distinguishes metabolites that are the inputs or outputs of a reaction.

Evolution of data flow. Graphical summary showing the design of short-term infrastructure initially deployed to support rapid delivery of unified data to the community and the planned production system. Red, data quartermasters at MODs; yellow, data; brown, database; green, transformations; blue, user interface.

Alliance curation tool. Screenshot of the Alliance curation tool interface showing an example of curated annotations of AGMs managed in the persistent store.

Textpresso for SGD literature at the Alliance (http://sgd-textpresso.alliancegenome.org/tpc/search).

Swagger interface for the Alliance APIs.

Alliance community forum home page.

Mockup of an expression detail page. This example shows one of the current features of WormBase—single-cell data from 2 studies—displayed on what will be part of an Alliance gene expression detail page.

Mockup of the AD portal showing the home page and the data access page. These views illustrate the type of information that will be available with a disease focus.