Lab
Drummond Lab
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Statement of Research Interest
The zebrafish pronephros as a model of kidney development.
We are studying the zebrafish pronephros in order to answer questions concerning early patterning events affecting kidney
development, epithelial cell differentiation, the generation of cell polarity, and the development of kidney vasculature. The
zebrafish pronephric kidney provides a simplified model of nephron development and epithelial cell differentiation which is
amenable to genetic analysis. By taking advantage of mutations affecting the pronephros, we are uncovering new aspects of
kidney cell differentiation.
We are studying the zebrafish pronephros in order to answer questions concerning early patterning events affecting kidney
development, epithelial cell differentiation, the generation of cell polarity, and the development of kidney vasculature. The
zebrafish pronephric kidney provides a simplified model of nephron development and epithelial cell differentiation which is
amenable to genetic analysis. By taking advantage of mutations affecting the pronephros, we are uncovering new aspects of
kidney cell differentiation.
Lab Members
| Liu, Yan Research Staff | Hellman, Nathan | Pathak, Naremdra |
- Schenk, H., Drummond, I.A. (2025) Kidney development, injury and regeneration-Zebrafish. Current topics in developmental biology. 163:307321307-321
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Djenoune, L., Tomar, R., Dorison, A., Ghobrial, I., Schenk, H., Hegermann, J., Beverly-Staggs, L., Hidalgo-Gonzalez, A., Little, M.H., Drummond, I.A. (2021) Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. Journal of the American Society of Nephrology : JASN. 32(7):1697-1712
- Babich, R., Ulrich, J.C., Ekanayake, E.M.D.V., Massarsky, A., De Silva, P.M.C.S., Manage, P.M., Jackson, B.P., Ferguson, P.L., Di Giulio, R.T., Drummond, I.A., Jayasundara, N. (2020) Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology. Environment International. 144:106019
- Sugano, Y., Siegfried, H., Merkel, E., Drummond, I.A. (2020) Novel Transgenic Lines to Analyze Renal Glutathione Redox Potential In Vivo. Zebrafish. 17:153-155
- Dong, S.S., Zhang, D.N., Zhang, Z.H., Yu, C.G., Liu, Y., Zhao, H.M., Wang, C.Y. (2019) [Ecotoxicological effects of transgenic mCry1Ac maize (BT799) on zebrafish]. Ying yong sheng tai xue bao = The journal of applied ecology. 30:2845-2853
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
- Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
- Bergboer, J.G.M., Wyatt, C., Austin-Tse, C., Yaksi, E., Drummond, I.A. (2018) Assaying sensory ciliopathies using calcium biosensor expression in zebrafish ciliated olfactory neurons. Cilia. 7:2
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