Lab
Bath Zebrafish Development Lab
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Statement of Research Interest
We are interested in understanding the cellular and genetic mechanisms of fate specification and patterning within the zebrafish neural crest. As our starting point we are analysing the extensive selection of zebrafish pigmentation mutants isolated in Tuebingen (Kelsh et al., 1996, Development 122, 369-389; Odenthal et al, 1996, Development 122, 391-398). We are testing hypotheses as to the process of pigment cell development from the neural crest that is affected in selected mutants. Further analysis is focussed on neural crest mutations that identify genes with key roles in pigment cell specification or patterning. We aim to characterise the pigment and other neural crest phenotypes in detail, and to test directly the role that the wild type gene has on crest development using molecular, cellular, and transplantation techniques. Recently we have become interested in the use of small molecules (chemical genetics) as a technique to further these studies.
Lab Members
Delfino-Machin, Mariana Post-Doc | Yang, Xueyan Post-Doc | Chipperfield, Tom Graduate Student |
Greenhill, Emma Graduate Student | Lee, Kui-Soon Graduate Student | Mueller, Jeanette Graduate Student |
Boyd, Amy Research Staff | Shedden, Marc Fish Facility Staff |
- Gjorcheska, S., Paudel, S., McLeod, S., Paulding, D., Snape, L., Sosa, K.C., Duan, C., Kelsh, R., Barske, L. (2025) Sox10 is required for systemic initiation of bone mineralization. Development (Cambridge, England). 152(2):
- Vassalli, Q.A., Fasano, G., Nittoli, V., Gagliardi, E., Sepe, R.M., Donizetti, A., Aniello, F., Sordino, P., Kelsh, R., Locascio, A. (2024) The Zebrafish Retina and the Evolution of the Onecut-Mediated Pathway in Cell Type Differentiation. Cells. 13(24):
- Miyadai, M., Takada, H., Shiraishi, A., Kimura, T., Watakabe, I., Kobayashi, H., Nagao, Y., Naruse, K., Higashijima, S.I., Shimizu, T., Kelsh, R.N., Hibi, M., Hashimoto, H. (2023) A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish. Development (Cambridge, England). 150(19):
- Subkhankulova, T., Camargo Sosa, K., Uroshlev, L.A., Nikaido, M., Shriever, N., Kasianov, A.S., Yang, X., Rodrigues, F.S.L.M., Carney, T.J., Bavister, G., Schwetlick, H., Dawes, J.H.P., Rocco, A., Makeev, V.J., Kelsh, R.N. (2023) Zebrafish pigment cells develop directly from persistent highly multipotent progenitors. Nature communications. 14:12581258
- Alhashem, Z., Feldner-Busztin, D., Revell, C., Alvarez-Garcillan Portillo, M., Camargo-Sosa, K., Richardson, J., Rocha, M., Gauert, A., Corbeaux, T., Milanetto, M., Argenton, F., Tiso, N., Kelsh, R., Prince, V.E., Bentley, K., Linker, C. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration. eLIFE. 11:
- Dawes, J.H.P., Kelsh, R.N. (2021) Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development. International Journal of Molecular Sciences. 22(24):
- Owen, J.P., Kelsh, R.N. (2021) A suitable anaesthetic protocol for metamorphic zebrafish. PLoS One. 16:e0246504
- Tsunogai, Y., Miyadai, M., Nagao, Y., Sugiwaka, K., Kelsh, R.N., Hibi, M., Hashimoto, H. (2021) Contribution of sox9b to pigment cell formation in medaka fish. Development, growth & differentiation. 63:516-522
- McCallum, S., Obata, Y., Fourli, E., Boeing, S., Peddie, C.J., Xu, Q., Horswell, S., Kelsh, R., Collinson, L., Wilkinson, D., Pin, C., Pachnis, V., Heanue, T.A. (2020) Enteric glia as a source of neural progenitors in adult zebrafish. eLIFE. 9:
- Owen, J.P., Kelsh, R.N., Yates, C.A. (2020) A quantitative modelling approach to zebrafish pigment pattern formation. eLIFE. 9:
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