Lab
Genevieve Kendall Lab
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Statement of Research Interest
Our team is focused on developing basic and translational models of pediatric sarcomas, which are devastating and aggressive solid tumors with limited therapeutic options. Specifically, we study fusion-driven rhabdomyosarcoma, which is thought to arise from a mis-regulation of skeletal muscle developmental pathways. We use cell culture and transgenic zebrafish systems to delineate the underlying biology of the disease and then apply that knowledge to identify molecular targets. Our ultimate goal is to apply our models as discovery-based tools to derive mechanistic insights for improving outcomes for children with cancer.
Lab Members
- Tallan, A., Kucinski, J., Sunkel, B., Taslim, C., LaHaye, S., Liu, Q., Qi, J., Wang, M., Kendall, G.C., Stanton, B.Z. (2025) Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing. Cell reports methods. :101052101052
- Harrison, E.N., Jay, A.N., Kent, M.R., Sukienik, T.P., LaVigne, C.A., Kendall, G.C. (2024) Engineering an fgfr4 knockout zebrafish to study its role in development and disease. PLoS One. 19:e0310100e0310100
- Kent, M.R., Silvius, K., Kucinski, J., Calderon, D., Kendall, G.C. (2024) Functional Genomics of Novel Rhabdomyosarcoma Fusion-Oncogenes Using Zebrafish. Methods in molecular biology (Clifton, N.J.). 2707:234123-41
- Silvius, K.M., Kendall, G.C. (2024) A Robust Closed-Tube Method for Resolving tp53M214K Genotypes. Zebrafish. 21(3):250-254
- Kent, M.R., Calderon, D., Silvius, K.M., Kucinski, J.P., LaVigne, C.A., Cannon, M.V., Kendall, G.C. (2023) Zebrafish her3 knockout impacts developmental and cancer-related gene signatures. Developmental Biology. 496:1141-14
- Watson, S., LaVigne, C.A., Xu, L., Surdez, D., Cyrta, J., Calderon, D., Cannon, M.V., Kent, M.R., Silvius, K.M., Kucinski, J.P., Harrison, E.N., Murchison, W., Rakheja, D., Tirode, F., Delattre, O., Amatruda, J.F., Kendall, G.C. (2023) VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. Cell Reports. 42:112013112013
- Fehrenbach, L.A., Adekanye, A.A., Palillo, M.B., Bidot, W.A., Malbrue, R.A., Coble, D.J., Kendall, G.C. (2022) Internal Temperatures of Packaging for Overnight Cross-country Shipping of Zebrafish (Danio rerio). Comparative medicine. 72(3):195-203
- Kendall, G.C., Watson, S., Xu, L., LaVigne, C.A., Murchison, W., Rakheja, D., Skapek, S.X., Tirode, F., Delattre, O., Amatruda, J.F. (2018) PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.. eLIFE. 7
- Kendall, G.C., Amatruda, J.F. (2016) Zebrafish as a Model for the Study of Solid Malignancies. Methods in molecular biology (Clifton, N.J.). 1451:121-42
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