Lab
Alexander Lab
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Statement of Research Interest
The Alexander lab is interested in generating novel zebrafish models of neuromuscular disorders for the purpose of drug screening and phenotypic evaluation. We seek to use zebrafish to better understand the disease processes and find novel treatments for dealing with human neuromuscular disorders.
Lab Members
| Reid, Andrea Post-Doc | Hightower, Rylie Graduate Student | Samani, Adrienne Graduate Student |
| Wang, Yimin Research Staff | Lopez, Michael |
- Huang, L., Simonian, R., Lopez, M.A., Karuppasamy, M., Sanders, V.M., English, K.G., Fabian, L., Alexander, M.S., Dowling, J.J. (2025) X-linked myopathy with excessive autophagy: characterization and therapy testing in a zebrafish model. EMBO Molecular Medicine. :
- Karuppasamy, M., English, K.G., Henry, C.A., Manzini, M.C., Parant, J.M., Wright, M.A., Ruparelia, A.A., Currie, P.D., Gupta, V.A., Dowling, J.J., Maves, L., Alexander, M.S. (2024) Standardization of zebrafish drug testing parameters for muscle diseases. Disease models & mechanisms. 17(1):
- English, K.G., Reid, A.L., Samani, A., Coulis, G.J.F., Villalta, S.A., Walker, C.J., Tamir, S., Alexander, M.S. (2022) Next-Generation SINE Compound KPT-8602 Ameliorates Dystrophic Pathology in Zebrafish and Mouse Models of DMD. Biomedicines. 10(10):
- Alexander, M.S., Hightower, R.M., Reid, A.L., Bennett, A.H., Iyer, L., Slonim, D.K., Saha, M., Kawahara, G., Kunkel, L.M., Kopin, A.S., Gupta, V.A., Kang, P.B., Draper, I. (2021) hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies. Muscle & nerve. 63(6):928-940
- Hightower, R.M., Reid, A.L., Gibbs, D.E., Wang, Y., Widrick, J.J., Kunkel, L.M., Kastenschmidt, J.M., Villalta, S.A., van Groen, T., Chang, H., Gornisiewicz, S., Landesman, Y., Tamir, S., Alexander, M.S. (2019) The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice. Molecular therapy : the journal of the American Society of Gene Therapy. 28(1):189-201
- Saha, M., Rizzo, S.A., Ramanathan, M., Hightower, R.M., Santostefano, K.E., Terada, N., Finkel, R.S., Berg, J.S., Chahin, N., Pacak, C.A., Wagner, R.E., Alexander, M.S., Draper, I., Kang, P.B. (2019) Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy. Human molecular genetics. 28:2365-2377
- Widrick, J.J., Kawahara, G., Alexander, M.S., Beggs, A.H., Kunkel, L.M. (2019) Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens. Journal of neuromuscular diseases. 6(3):271-287
- Serafini, P.R., Feyder, M.J., Hightower, R.M., Garcia-Perez, D., Vieira, N.M., Lek, A., Gibbs, D.E., Moukha-Chafiq, O., Augelli-Szafran, C.E., Kawahara, G., Widrick, J.J., Kunkel, L.M., Alexander, M.S. (2018) A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies. JCI insight. 3(18):
- Ignatius, M.S., Hayes, M.N., Lobbardi, R., Chen, E.Y., McCarthy, K.M., Sreenivas, P., Motala, Z., Durbin, A.D., Molodtsov, A., Reeder, S., Jin, A., Sindiri, S., Beleyea, B.C., Bhere, D., Alexander, M.S., Shah, K., Keller, C., Linardic, C.M., Nielsen, P.G., Malkin, D., Khan, J., Langenau, D.M. (2017) The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Reports. 19:2304-2318
- Vieira, N.M., Spinazzola, J.M., Alexander, M.S., Moreira, Y.B., Kawahara, G., Gibbs, D.E., Mead, L.C., Verjovski-Almeida, S., Zatz, M., Kunkel, L.M. (2017) Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 114(23):6080-6085
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