Lab
Jing-Xia Liu Lab
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Statement of Research Interest
We are interested in the interactive regulation networks between environmental factors including drugs, metal ions and their nanoparticles (outside of cells) and genes (in cells ) in regulating development and regeneration of hematopoietic system (hematopoietic cells/ hematopoietic stem cells) and locomotor behavior systems by approaches of chemical screens, genetic screens, and biochemical analysis in zebrafish and in human cell lines. Another aim of our lab is to reveal the cooperativity of the genetic and epigenetic regulators in all steps of adaptive evolution to environmental factors during fish development by applying comparative genomics between short-time transcriptome responses and long-time regulatory adaptations.
Lab Members
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Tai, Z., Li, L., Zhao, G., Liu, J.X. (2022) Copper stress impairs angiogenesis and lymphangiogenesis during zebrafish embryogenesis by down-regulating pERK1/2-foxm1-MMP2/9 axis and epigenetically regulating ccbe1 expression. Angiogenesis. 25(2):241-257
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Tai, Z., Guan, P., Zhang, T., Liu, W., Li, L., Wu, Y., Li, G., Liu, J.X. (2021) Effects of parental environmental copper stress on offspring development: DNA methylation modification and responses of differentially methylated region-related genes in transcriptional expression. Journal of hazardous materials. 424(Pt C):127600
- Zhang, T., Guan, P., Liu, W., Zhao, G., Fang, Y., Fu, H., Gui, J.F., Li, G., Liu, J.X. (2020) Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms. 1863(10):194612
- Zhao, G., Sun, H., Zhang, T., Liu, J.X. (2020) Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Cell communication and signaling : CCS. 18:45
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
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