Lab
Le Noble Lab
|
|
Statement of Research Interest
Our goal is to generate novel genetic insights in the regulation of vascular development and arterial-venous vessel identity that can translate into therapeutic strategies. Our research projects aim at understanding the molecular regulation of angiogenesis and arteriogenesis.
We focus on four crucial aspects:
1) Formation of angiogenic sprouts and guidance of vessel sprouts by endothelial tip cells (Nature 2004, Development 2011; Circulation Research, 2012)
2) Imprinting of arterial-venous venous vessel identity by neural guidance genes and hemodynamic factors (Development 2004; Development 2012).
3) Formation, recruitment and growth of (native) arterial collateral networks in ischemic cardiovascular diseases (Circulation Research 2011; Development 2013)
4) Identification of evolutionary conserved principles of vascular and neuronal differentiation and patterning
For this purpose we characterize the mechanisms of vascular and neuronal development in experimental models including (transgenic) zebrafish, chick and mouse embryo. In addition, the concepts emerging from understanding the basic molecular principles governing vascular growth are translated into relevant pathologic settings including cerebral and cardiac ischemia models, and cancer. We specifically address arterial collateral development upon arterial occlusion and prevention-recovery from target organ damage (heart infarct, stroke).
We focus on four crucial aspects:
1) Formation of angiogenic sprouts and guidance of vessel sprouts by endothelial tip cells (Nature 2004, Development 2011; Circulation Research, 2012)
2) Imprinting of arterial-venous venous vessel identity by neural guidance genes and hemodynamic factors (Development 2004; Development 2012).
3) Formation, recruitment and growth of (native) arterial collateral networks in ischemic cardiovascular diseases (Circulation Research 2011; Development 2013)
4) Identification of evolutionary conserved principles of vascular and neuronal differentiation and patterning
For this purpose we characterize the mechanisms of vascular and neuronal development in experimental models including (transgenic) zebrafish, chick and mouse embryo. In addition, the concepts emerging from understanding the basic molecular principles governing vascular growth are translated into relevant pathologic settings including cerebral and cardiac ischemia models, and cancer. We specifically address arterial collateral development upon arterial occlusion and prevention-recovery from target organ damage (heart infarct, stroke).
Lab Members
| Gradl, Dietmar Post-Doc | Préau, Laetitia Post-Doc | Wild, Raphael Graduate Student |
- Kinghorn, K., Gill, A., Marvin, A., Li, R., Quigley, K., Singh, S., Gore, M.T., le Noble, F., Gabhann, F.M., Bautch, V.L. (2023) A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells. Angiogenesis. 27(1):67-89
- Afonin, S., Koniev, S., Préau, L., Takamiya, M., Strizhak, A.V., Babii, O., Hrebonkin, A., Pivovarenko, V.G., Dathe, M., le Noble, F., Rastegar, S., Strähle, U., Ulrich, A.S., Komarov, I.V. (2021) In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid. Frontiers in chemistry. 9:688446
- Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
- Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724
- Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991
- Ziegler, T., Hinkel, R., Stöhr, A., Eschenhagen, T., Laugwitz, K.L., le Noble, F., David, R., Hansen, A., Kupatt, C. (2017) Thymosin β4 Improves Differentiation and Vascularization of EHTs.. Stem Cells International. 2017:6848271
- Brinkmann, E.M., Mattes, B., Kumar, R., Hagemann, A.I., Gradl, D., Scholpp, S., Steinbeisser, H., Kaufmann, L.T., Ozbek, S. (2016) Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. The Journal of biological chemistry. 291(26):13730-42
- Wang, X., Yuan, W., Wang, X., Qi, J., Qin, Y., Shi, Y., Zhang, J., Gong, J., Dong, Z., Liu, X., Sun, C., Chai, R., Le Noble, F., Liu, D. (2016) The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget. 7(47):77749-77763
- Jiang, Q., Lagos-Quintana, M., Liu, D., Shi, Y., Helker, C., Herzog, W., and le Noble, F. (2013) miR-30a Regulates Endothelial Tip Cell Formation and Arteriolar Branching. Hypertension (Dallas, Tex. : 1979). 62(3):592-8
- Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F., and Rajewsky, N. (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495(7441):333-8
1 - 10 of 10
Show