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Statement of Research Interest

The Choi laboratory studies molecular mechanisms of human genetic diseases and motile ciliogenesis using zebrafish as a model organism.

Lab Members

Lee, So-Hyun Post-Doc

Zebrafish Publications of lab members

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• Lee, S.H., Liang, T., Chandrasekaran, G., Zhang, J., Kim, S.S., Parvathi, S.V., Lee, S.W., Cho, E.S., Shin, H.Y., Yoon, Y.G., Jo, J., Bae, M.A., Choi, S.Y., Kim, M.K. (2025) Mutant zebrafish lacking slc25a22a show spontaneous seizures and respond to the anti-seizure medication valproic acid. Disease models & mechanisms. 18:
• Lee, G.B., Chandrasekaran, G., Kim, H.J., Kim, P., Yoon, J., Choi, B.W., Lee, S.H., Lee, S.Y., Shin, D.S., Lee, B.H., Bae, M.A., Goughnour, P., Choi, E.Y., Choi, S.Y., Ahn, J.H. (2024) Discovery of novel arylpyridine derivatives for motile ciliogenesis. European Journal of Medicinal Chemistry. 277:116764116764
• Mohapatra, A., Rajendrakumar, S.K., Chandrasekaran, G., Revuri, V., Sathiyamoorthy, P., Lee, Y.K., Lee, J.H., Choi, S.Y., Park, I.K. (2023) Biomineralized Nanoscavenger Abrogates Proinflammatory Macrophage Polarization and Induces Neutrophil Clearance through Reverse Migration during Gouty Arthritis. ACS applied materials & interfaces. 15(3):3812-3825
• Fortibui, M.M., Jang, M., Lee, S., Ryoo, I.J., Ahn, J.S., Ko, S.K., Kim, J. (2022) Near-Infrared Fluorescence Probe for Specific Detection of Acetylcholinesterase and Imaging in Live Cells and Zebrafish. ACS applied bio materials. 5(5):2232-2239
• Jang, J.Y., Liang, T., Kim, M.K., Kang, K.W., Lee, B., Choi, S.Y. (2022) A Rapid and Noninvasive Method That Extracts Polymerase Chain Reaction-Ready Genomic DNA from Adult Zebrafish. Zebrafish. 19(4):160-164
• In Ka, H., Seo, H., Choi, Y., Kim, J., Cho, M., Choi, S.Y., Park, S., Han, S., An, J., Chung, H.S., Yang, Y., Kim, M.J. (2021) Loss of splicing factor IK impairs normal skeletal muscle development. BMC Biology. 19:44
• Zhang, J., Chandrasekaran, G., Li, W., Kim, D.Y., Jeong, I.Y., Lee, S.H., Liang, T., Bae, J.Y., Choi, I., Kang, H., Maeng, J.S., Kim, M.K., Lee, T., Park, S.W., Kim, M.J., Kim, H.S., Ro, H., Bae, Y.C., Park, H.C., Choi, E.Y., Choi, S.Y. (2020) Wnt-PLC-IP₃-Connexin-Ca²⁺ axis maintains ependymal motile cilia in zebrafish spinal cord. Nature communications. 11:1860
• Jeong, J., Kim, K.H., Kim, D.Y., Chandrasekaran, G., Kim, M., Pagire, S.H., Dighe, M., Choi, E.Y., Bak, S.M., Kim, E.Y., Shin, M.G., Choi, S.Y., Ahn, J.H. (2019) Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model. Bioorganic & Medicinal Chemistry. 27(19):115014
• Nam, T.S., Zhang, J., Chandrasekaran, G., Jeong, I.Y., Li, W., Lee, S.H., Kang, K.W., Maeng, J.S., Kang, H., Shin, H.Y., Park, H.C., Kim, S., Choi, S.Y., Kim, M.K. (2019) A zebrafish model of nondystrophic myotonia with sodium channelopathy. Neuroscience letters. 714:134579
• Cho, S.J., Byun, D., Nam, T.S., Choi, S.Y., Lee, B.G., Kim, M.K., Kim, S. (2017) A 3D-Printed Sensor for Monitoring Biosignals in Small Animals. Journal of healthcare engineering. 2017:9053764

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