Lab
Chunyue Yin Lab
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Statement of Research Interest
The long-term goal in the Yin lab is to understand the molecular and cellular mechanisms underlying liver development, regeneration and disease pathogenesis. Our projects use a combination of genetic, molecular, embryology, biochemical, and cell biological approaches in the zebrafish model to address questions related to liver biology.
Currently, there are two main focuses in the lab. The first one is to delineate the regulation of hepatic stellate cells, the key cell type responsible for liver fibrosis, during liver development and injury. The second one is to understand the cell biology of hepatic biliary cells in the zebrafish models of biliary diseases.
Currently, there are two main focuses in the lab. The first one is to delineate the regulation of hepatic stellate cells, the key cell type responsible for liver fibrosis, during liver development and injury. The second one is to understand the cell biology of hepatic biliary cells in the zebrafish models of biliary diseases.
Lab Members
Ellis, Jillian Research Staff |
- Karolczak, S., Deshwar, A.R., Aristegui, E., Kamath, B.M., Lawlor, M.W., Andreoletti, G., Volpatti, J.R., Ellis, J.L., Yin, C., Dowling, J.J. (2023) Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy. The Journal of Clinical Investigation. 133(18):
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Pham, D.H., Kudira, R., Xu, L., Valencia, C.A., Ellis, J.L., Shi, T., Evason, K.J., Osuji, I., Matuschek, N., Pfuher, L., Mullen, M., Mohanty, S.K., Husami, A., Bull, L.N., Zhang, K., Wali, S., Yin, C., Miethke, A. (2021) Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms: ABCC12 pathogenic variants lead to cholestasis. Gastroenterology. 161(1):287-300.e16
- DeRossi, C., Bambino, K., Morrison, J., Sakarin, I., Villacorta-Martin, C., Zhang, C., Ellis, J.L., Fiel, M.I., Ybanez, M., Lee, Y.A., Huang, K.L., Yin, C., Sakaguchi, T.F., Friedman, S.L., Villanueva, A., Chu, J. (2019) Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology (Baltimore, Md.). 70(6):2107-2122
- Pham, D.H., Yin, C. (2019) Zebrafish as a Model to Study Cholestatic Liver Diseases. Methods in molecular biology (Clifton, N.J.). 1981:273-289
- Shwartz, A., Goessling, W., Yin, C. (2019) Macrophages in Zebrafish Models of Liver Diseases. Frontiers in immunology. 10:2840
- Williams, M.L.K., Sawada, A., Budine, T., Yin, C., Gontarz, P., Solnica-Krezel, L. (2018) Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes. Nature communications. 9:1319
- Ellis, J.L., Bove, K.E., Schuetz, E.G., Leino, D., Valencia, C.A., Schuetz, J.D., Miethke, A., Yin, C. (2017) Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency. Hepatology (Baltimore, Md.). 67(4):1531-1545
- Pham, D.H., Zhang, C., Yin, C. (2017) Using zebrafish to model liver diseases-Where do we stand?. Current pathobiology reports. 5:207-221
- Yang, Q., Yan, C., Yin, C., Gong, Z. (2017) Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. Cellular and molecular gastroenterology and hepatology. 3:484-499
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