Lab
Yariv Houvras Laboratory
|
![]() |
Statement of Research Interest
Our laboratory uses zebrafish to model human cancer. We are particularly interested in using zebrafish to discover new oncogenes and understand the epigenetic basis of malignancy.
Lab Members
Casa, Angelo Post-Doc | Bourque, Caitlin Fish Facility Staff | Zack, Yael |
- Neelamraju, Y., Gjini, E., Chhangawala, S., Fan, H., He, S., Jing, C.B., Nguyen, A.T., Prajapati, S., Sheridan, C., Houvras, Y., Melnick, A., Look, A.T., Garrett-Bakelman, F.E. (2023) Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome. Frontiers in hematology. 2:
- DiNapoli, S.E., Martinez-McFaline, R., Shen, H., Doane, A.S., Perez, A.R., Verma, A., Simon, A., Nelson, I., Balgobin, C.A., Bourque, C.T., Yao, J., Raman, R., Béguelin, W., Zippin, J.H., Elemento, O., Melnick, A.M., Houvras, Y. (2022) Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. Frontiers in cell and developmental biology. 10:814216
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Maskin, C.R., Raman, R., Houvras, Y. (2022) PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity. Scientific Reports. 12:5573
- DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y. (2020) Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research. 48(7):e38
- Salhi, A., Jordan, A.C., Bochaca, I.I., Izsak, A., Darvishian, F., Houvras, Y., Giles, K.M., Osman, I. (2020) Oxidative phosphorylation promotes primary melanoma invasion. The American journal of pathology. 190(5):1108-1117
- Weeks, O., Bossé, G.D., Oderberg, I.M., Akle, S., Houvras, Y., Wrighton, P.J., LaBella, K., Iversen, I., Tavakoli, S., Adatto, I., Schwartz, A., Kloosterman, D., Tsomides, A., Charness, M.E., Peterson, R.T., Steinhauser, M.L., Fazeli, P.K., Goessling, W. (2020) Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. The Journal of Clinical Investigation. 130(5):2252-2269
- Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
- Cox, A.G., Tsomides, A., Yimlamai, D., Hwang, K.L., Miesfeld, J., Galli, G.G., Fowl, B.H., Fort, M., Ma, K.Y., Sullivan, M.R., Hosios, A.M., Snay, E., Yuan, M., Brown, K.K., Lien, E.C., Chhangawala, S., Steinhauser, M.L., Asara, J.M., Houvras, Y., Link, B., Vander Heiden, M.G., Camargo, F.D., Goessling, W. (2018) Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. The EMBO journal. 37(22):
- Anelli, V., Villefranc, J.A., Chhangawala, S., Martinez-McFaline, R., Riva, E., Nguyen, A., Verma, A., Bareja, R., Chen, Z., Scognamiglio, T., Elemento, O., Houvras, Y. (2017) Oncogenic BRAF disrupts thyroid morphogenesis and function via Twist expression. eLIFE. 6
1 - 10 of 27
Show