Lab
Fleming Lab
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Statement of Research Interest
Lab Members
| Sanchez-Elexpuru, Gentzane Post-Doc | Kulkarni, Sanika Graduate Student | Pickering, Jake Graduate Student |
- Son, S.M., Siddiqi, F.H., Lopez, A., Ansari, R., Tyrkalska, S.D., Park, S.J., Kunath, T., Metzakopian, E., Fleming, A., Rubinsztein, D.C. (2025) Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition. Neuron. :
- Lopez, A., Siddiqi, F.H., Villeneuve, J., Ureshino, R.P., Jeon, H.Y., Koulousakis, P., Keeling, S., McEwan, W.A., Fleming, A., Rubinsztein, D.C. (2024) Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion. Nature Chemical Biology. :
- Zhu, Y., Fujimaki, M., Snape, L., Lopez, A., Fleming, A., Rubinsztein, D.C. (2024) Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis. Nature cell biology. 26(4):542-551
- Sneddon, L.U., Schroeder, P., Roque, A., Finger-Baier, K., Fleming, A., Tinman, S., Collet, B. (2023) Pain management in zebrafish : Report from a FELASA Working Group. Laboratory animals. 58(3):261-276
- Fleming, A., Xuan, L.Z., Sanchez-Elexpuru, G., Williams, S.V., Windell, D., Gelb, M.H., Herbst, Z.M., Schlotawa, L., Rubinsztein, D.C. (2022) Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency. Frontiers in cell and developmental biology. 10:843079
- Lopez, A., Gorb, A., Palha, N., Fleming, A., Rubinsztein, D.C. (2022) A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo. Genes. 13(5)
- Schlotawa, L., Lopez, A., Sanchez-Elexpuru, G., Tyrkalska, S.D., Rubinsztein, D.C., Fleming, A. (2022) An inducible expression system for the manipulation of autophagic flux in vivo. Autophagy. 19(5):1582-1595
- Iqbal, A., Baldrighi, M., Murdoch, J.N., Fleming, A., Wilkinson, C.J. (2020) Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome. Biology Open. 9(10):
- Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902
- VerPlank, J.J.S., Tyrkalska, S.D., Fleming, A., Rubinsztein, D.C., Goldberg, A.L. (2020) cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. 117(25):14220-14230
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