Lab
Koehler Lab
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Statement of Research Interest
Lab Members
- Langenbacher, A.D., Shimizu, H., Hsu, W., Zhao, Y., Borges, A., Koehler, C., Chen, J.N. (2020) Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia. Frontiers in Physiology. 11:617492
- Francois-Moutal, L., Jahanbakhsh, S., Nelson, A., Ray, D., Scott, D.D., Hennefarth, M., Moutal, A., Perez-Miller, S., Ambrose, A.J., Al-Shamari, A., Coursodon, P., Meechoovet, B., Reiman, R., Lyons, E., Beilstein, M., Chapman, E., Morris, Q.D., Van Keuren-Jensen, K., Hughes, T.R., Khanna, R., Koehler, C., Jen, J., Gokhale, V., Khanna, M. (2018) A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). ACS Chemical Biology. 13(10):3000-3010
- Yien, Y.Y., Shi, J., Chen, C., Cheung, J.T., Grillo, A.S., Shrestha, R., Li, L., Zhang, X., Kafina, M.D., Kingsley, P.D., King, M.J., Ablain, J., Li, H., Zon, L., Palis, J., Burke, M.D., Bauer, D.E., Orkin, S.H., Koehler, C.M., Phillips, J.D., Kaplan, J., Ward, D.M., Lodish, H.F., Paw, B.H. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of biological chemistry. 293(51):19797-19811
- Miyata, N., Tang, Z., Conti, M.A., Johnson, M.E., Douglas, C.J., Hasson, S.A., Damoiseaux, R., Chang, C.A., Koehler, C.M. (2017) Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. The Journal of biological chemistry. 292:5429-5442
- Sangwan, S., Zhao, A., Adams, K.L., Jayson, C.K., Sawaya, M.R., Guenther, E.L., Pan, A.C., Ngo, J., Moore, D.M., Soriaga, A.B., Do, T.D., Goldschmidt, L., Nelson, R., Bowers, M.T., Koehler, C.M., Shaw, D.E., Novitch, B.G., Eisenberg, D.S. (2017) Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proceedings of the National Academy of Sciences of the United States of America. 114(33):8770-8775
- Wan, J., Steffen, J., Yourshaw, M., Mamsa, H., Andersen, E., Rudnik-Schöneborn, S., Pope, K., Howell, K.B., McLean, C.A., Kornberg, A.J., Joseph, J., Lockhart, P.J., Zerres, K., Ryan, M.M., Nelson, S.F., Koehler, C.M., Jen, J.C. (2016) Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia. Brain : a journal of neurology. 139(11):2877-2890
- Miyata, N., Steffen, J., Johnson, M.E., Fargue, S., Danpure, C.J., Koehler, C.M. (2014) Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. Proceedings of the National Academy of Sciences of the United States of America. 111:14406-11
- Yien, Y. Y., Robledo, R. F., Schultz, I. J., Takahashi-Makise, N., Gwynn, B., Bauer, D. E., Bass, A., Yi, G., Li, L., Hildick-Smith, G. J., Cooney, J. D., Pierce, E. L., Mohler, K., Dailey, T. A., Miyata, N., Kingsley, P. D., Garone, C., Hattangadi, S. M., Huang, H., Chen, W., Keenan, E. M., Shah, D. I., Schlaeger, T. M., DiMauro, S., Orkin, S. H., Cantor, A. B., Palis, J., Koehler, C. M., Lodish, H. F., Kaplan, J., Ward, D. M., Dailey, H. A., Phillips, J. D., Peters, L. L., Paw, B. H. (2014) TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124(10):4294-4304
- Dabir, D.V., Hasson, S.A., Setoguchi, K., Johnson, M.E., Wongkongkathep, P., Douglas, C.J., Zimmerman, J., Damoiseaux, R., Teitell, M.A., and Koehler, C.M. (2013) A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Developmental Cell. 25(1):81-92
- Hildick-Smith, G.J., Cooney, J.D., Garone, C., Kremer, L.S., Haack, T.B., Thon, J.N., Miyata, N., Lieber, D.S., Calvo, S.E., Akman, H.O., Yien, Y.Y., Huston, N.C., Branco, D.S., Shah, D.I., Freedman, M.L., Koehler, C.M., Italiano, J.E., Merkenschlager, A., Beblo, S., Strom, T.M., Meitinger, T., Freisinger, P., Donati, M.A., Prokisch, H., Mootha, V.K., Dimauro, S., and Paw, B.H. (2013) Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4. American journal of human genetics. 93(5):906-14
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