GSK-J4

Term ID

CHEBI:95077

Synonyms

• 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid ethyl ester
• ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate
• ethyl N-[2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)pyrimidin-4-yl]-beta-alaninate
• GSK J4
• GSKJ4

Definition

A member of the class of aminopyrimidines that is pyrimidine substituted by pyridin-2-yl, 3-ethoxy-3-oxopropylamino, and 1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl groups at positions 2, 4, and 6, respectively. It is an inhibitor of the histone demethylase JMJD3/UTX.

References

• CAS:1373423-53-0
• HMDB:HMDB0252948
• LINCS:LSM-6328
• PMCID:PMC10670038
• PMCID:PMC6217190
• PMCID:PMC7651554
• PMID:22842901
• PMID:29047260
• PMID:31241814
• PMID:31506334
• PMID:32178714
• PMID:32393321
• PMID:32477122
• PMID:32514253
• PMID:33446666
• PMID:35430567
• PMID:35722096
• PMID:36012674
• PMID:36531063
• PMID:36768182
• PMID:36792181
• PMID:36874364
• PMID:37165737
• PMID:37330650
• PMID:37566089
• PMID:38001607
• PMID:38317193
• PMID:38393716
• PMID:38499211
• PMID:39036915
• PMID:39307916
• PMID:39482699
• PMID:39577709
• PMID:39791538
• PMID:39813767

Ontology

ChEBI  ( EBI )