Search Ontology:
ChEBI

SU11274

Term ID
CHEBI:190974
Synonyms
  • (3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
  • PKI-SU11274
  • SU 11274
  • SU-11274
(all 4)
Definition
A member of the class of oxindoles that is 1,3-dihydro-2H-indol-2-one substituted by {3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene and N-(3-chlorophenyl)-N-methylmethanesulfonyl groups at positions 3 and 5, respectively. It is a potent ATP-competitive inhibitor of c-Met (IC50 = 20 nM) and exhibits antineoplastic activity.
References
(all 38)
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from SU11274
Phenotype where environments contain SU11274
Phenotype modified by environments containing SU11274
Phenotype affecting SU11274
Human Disease Model
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