Term Name: | keratan sulfate proteoglycan biosynthetic process |
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Synonyms: | keratan sulfate anabolism, keratan sulfate biosynthesis, keratan sulfate formation, keratan sulfate synthesis, keratan sulphate biosynthesis, keratan sulphate biosynthetic process |
Definition: | The chemical reactions and pathways resulting in the formation of keratan sulfate proteoglycans, which consist of a core protein linked to a keratan sulfate glycosaminoglycan. The keratan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-beta-(1,3)-galactose, both of which can be sulfated. Keratan sulfate chains can be covalently linked either to an asparagine residue (N-linked) of the core protein via a high mannose oligasacccharide linker or to serine/threonine residues (O-linked) of the core protein via a core 2 type-linker. |
Ontology: | GO: Biological Process [GO:0018146] QuickGO AmiGO |