Term Name: 6-O-methylguanine
Synonyms: 2-Amino-6-methoxypurine, 6-Methoxy-1H-purine-2-amine, 6-methoxy-7H-purin-2-amine, 6-Methoxyguanine, O(6)-methylguanine, O-(6)-Methylguanine
Definition: A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
Ontology: ChEBI [CHEBI:20689]  ( EBI )

Relationships
is a type of: methylguanine
has_role: mutagen