| ZFIN ID: ZDB-EXP-250708-6 |
Experiment Conditions Description: chemical treatment by environment: WIN 18446, amputation: caudal fin
| chemical treatment by environment: WIN 18446 |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | WIN 18446 |
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| Synonyms: | Fertilysin, Fertilysine, N,N'-1,8-Octanediylbis(2,2-dichloroacetamide), N,N'-bis(dichloracetyl)-1,8-octanediamine, N,N'-bis(dichloroacetyl)-1,8-diaminooctane, N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine, N,N'-octamethylenebis(2,2-dichloro-N-ethylacetamide), N,N'-octamethylenebis(2,2-dichloroacetamide), N,N'-octane-1,8-diylbis(2,2-dichloroacetamide), WIN 18,446, Win-18446, WIN18446 |
| Definition: | A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish. |
| Ontology: | ChEBI [CHEBI:90441] ( EBI ) |
| amputation: caudal fin |
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| Name: | amputation |
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| Synonyms: | |
| Definition: | Resection condtion in which all or part of an extremity such as the fin or tail are removed. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000172] |
| Name: | caudal fin |
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| Synonyms: | tail, tail fin |
| Definition: | Fin that is the most posterior median fin. It is composed of a complex of three modified centra and modified neural and hemal arches and spines. |
| Ontology: | Anatomy Ontology [ZFA:0001058] |
| Publication: | Seaver et al., 2023 |
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