PUBLICATION

Hematopoietic mutations in the zebrafish

Authors
Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C.
ID
ZDB-PUB-970210-26
Date
1996
Source
Development (Cambridge, England)   123: 303-309 (Journal)
Registered Authors
Abdelilah-Seyfried, Salim, Driever, Wolfgang, Fishman, Mark C., Malicki, Jarema, Schier, Alexander, Solnica-Krezel, Lilianna, Stainier, Didier, Stemple, Derek L., Weinstein, Brant M.
Keywords
primitive haematopoiesis; mutations; zebrafish
MeSH Terms
  • Zebrafish/blood
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Cell Differentiation/genetics
  • Mutation*
  • Light/adverse effects
  • Animals
  • Embryo, Nonmammalian/blood supply
  • Blood Cells/pathology
  • Hematopoiesis/genetics*
  • Hemolysis/genetics
(all 11)
PubMed
9007250 Full text @ Development
Abstract
We have identified mutations that perturb the formation or differentiation of the first embryonic blood cells in the zebrafish embryo. These 'primitive' red blood cells originate in the intermediate cell mass of the trunk, a derivative of the dorsal lateral plate mesoderm. By transfusion of blood between embryos we demonstrate that this cohort of cells provides the embryo with all, or nearly all, of its blood cells until at least day 5 postfertilization. Larval lethal mutations generated by ENU mutagenesis affect different steps in the development of these cells. Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity.
Genes / Markers
Figures
Figure Gallery (4 images)
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Expression
No data available
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
m62
    Unknown
    m87
      Unknown
      m159
        Unknown
        m232
          Unknown
          m248
            Point Mutation
            m262
              Point Mutation
              m328
                Unknown
                m416
                  Unknown
                  m525
                    Unknown
                    m534
                      Unknown
                      1 - 10 of 13
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                      Human Disease / Model
                      No data available
                      Sequence Targeting Reagents
                      No data available
                      Fish
                      Antibodies
                      No data available
                      Orthology
                      No data available
                      Engineered Foreign Genes
                      No data available
                      Mapping
                      No data available