PUBLICATION

Genetic analysis of fin formation in the zebrafish, Danio rerio

Authors
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C.
ID
ZDB-PUB-970210-21
Date
1996
Source
Development (Cambridge, England)   123: 255-262 (Journal)
Registered Authors
Brand, Michael, Furutani-Seiki, Makoto, Granato, Michael, Haffter, Pascal, Hammerschmidt, Matthias, Heisenberg, Carl-Philipp, Jiang, Yun-Jin, Kane, Donald A., Kelsh, Robert, Mullins, Mary C., Nüsslein-Volhard, Christiane, Odenthal, Joerg, van Eeden, Freek, Warga, Rachel M.
Keywords
embryonic fin fold; pectoral fins; sonic hedgehog; adult fins; skin; zebrafish
MeSH Terms
  • Larva/genetics
  • Larva/growth & development
  • Tail/embryology
  • Skin/embryology
  • Extremities/embryology*
  • Extremities/growth & development
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Animals
  • Phenotype
  • Mutation*
  • Pectoralis Muscles
(all 13)
PubMed
9007245 Full text @ Development
Abstract
In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during embryogenesis. At larval stages the caudal fin fold is replaced by four different fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins are formed. We have identified a total of 118 mutations affecting larval fin formation. Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal and pectoral fin folds. Most mutants survive to adulthood and form a surprisingly normal complement of adult fins. Mutations in nine genes result in an increased or reduced size of the pectoral fins. Interestingly, in mutants of one of these genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium fails to expand. Expression of sonic hedgehog mRNA in the posterior mesenchyme of the pectoral fin bud is initiated in dak embryos, but not maintained. Mutations in five other genes affect adult fin but not larval fin development. Two mutants, longfin (lof) and another longfin (alf) have generally longer fins. Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins. Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported.
Genes / Markers
Figures
Figure Gallery (7 images)
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
dt2
    Unknown
    dti216c
      Point Mutation
      dty40
        Point Mutation
        ta50
          Unknown
          ta52b
            Point Mutation
            ta72a
              Point Mutation
              ta84
                Unknown
                ta90
                  Point Mutation
                  ta206
                    Unknown
                    tb22
                      Unknown
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                      Human Disease / Model
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                      Sequence Targeting Reagents
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                      Fish
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                      Orthology
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                      Engineered Foreign Genes
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                      Mapping
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