PUBLICATION

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio

Authors
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C.
ID
ZDB-PUB-970210-12
Date
1996
Source
Development (Cambridge, England)   123: 143-151 (Journal)
Registered Authors
Brand, Michael, Furutani-Seiki, Makoto, Granato, Michael, Haffter, Pascal, Hammerschmidt, Matthias, Heisenberg, Carl-Philipp, Jiang, Yun-Jin, Kane, Donald A., Kelsh, Robert, Mullins, Mary C., Nüsslein-Volhard, Christiane, Odenthal, Joerg, Pelegri, Francisco, van Eeden, Freek, Warga, Rachel M.
Keywords
zebrafish; gastrulation; tail formation; axis extension; cyclopia; one-eyed-pinhead; spadetail; trilobite; pipetail; kugelig
MeSH Terms
  • Animals
  • Gene Expression Regulation, Developmental
  • Mutation*
  • Ectoderm/metabolism
  • Genes
  • Tail/embryology*
  • Movement
  • Gastrula/physiology*
  • Mesoderm/metabolism
  • Nervous System/embryology
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Morphogenesis/genetics
(all 13)
PubMed
9007236 Full text @ Development
Abstract
We have identified several genes that are required for various morphogenetic processes during gastrulation and tail formation. Two genes are required in the anterior region of the body axis: one eyed pinhead (oep) and dirty nose (dns).oep mutant embryos are defective in prechordal plate formation and the specification of anterior and ventral structures of the central nervous system. In dns mutants, cells of the prechordal plate, such as the prospective hatching gland cells, fail to specify. Two genes are required for convergence and extension movements. In mutant trilobite embryos, extension movements on the dorsal side of the embryo are affected, whereas in the formerly described spadetail mutants, for which two new alleles have been isolated, convergent movements of ventrolateral cells to the dorsal side are blocked. Two genes are required for the development of the posterior end of the body axis. In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac.
Genes / Markers
Figures
Figure Gallery (5 images)
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Expression
Phenotype
Fish Conditions Stage Phenotype Figure
cdh2tb8/tb8standard conditionsBud to Prim-5
cdh2tb8/tb8standard conditionsBud to Prim-5
cdh2tb8/tb8standard conditionsBud to Prim-5
cdh2tb8/tb8standard conditionsBud to Prim-5
cdh2tb8/tb8standard conditionsBud to Prim-5
cdh2tb8/tb8standard conditionsBud to Prim-5
cdx4tl240a/tl240astandard conditions14-19 somites
cdx4tl240a/tl240astandard conditions20-25 somites
cdx4tl240a/tl240astandard conditions20-25 somites
cdx4tl240a/tl240astandard conditions20-25 somites
1 - 10 of 228
Show
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
b104
    		Indel
    m423
      		Point Mutation
      m747
        		Point Mutation
        ta65a
          		Unknown
          ta76a
            		Unknown
            ta98
              		Point Mutation
              tb8
                		Point Mutation
                tb233a
                  		Unknown
                  tc223
                    		Unknown
                    tc240
                      		Insertion
                      1 - 10 of 33
                      Show
                      Human Disease / Model
                      No data available
                      Sequence Targeting Reagents
                      No data available
                      Fish
                      Fish
                      cdh2tb8/tb8
                      cdx4tl240a/tl240a
                      cdx4tv205c/tv205c
                      dnste350/te350
                      gon4lbtu24/tu24
                      indti228e/ti228e
                      mptts292f/ts292f
                      samtb233a/tb233a
                      schtr284/tr284
                      szltm305/tm305
                      1 - 10 of 34
                      Show
                      Antibodies
                      No data available
                      Orthology
                      No data available
                      Engineered Foreign Genes
                      No data available
                      Mapping
                      No data available
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                      Citation
                      Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:143-151.