PUBLICATION
Chr23-miR-200s and Dmrt1 Control Sexually Dimorphic Trade-Off Between Reproduction and Growth in Zebrafish
- Authors
- Ge, S., Liu, Y., Huang, H., Yu, J., Li, X., Lin, Q., Huang, P., Mei, J.
- ID
- ZDB-PUB-250226-23
- Date
- 2025
- Source
- International Journal of Molecular Sciences 26: (Journal)
- Registered Authors
- Mei, Jie
- Keywords
- Dmrt1, growth, miR-200, reproduction, sexual dimorphism, trade-off
- MeSH Terms
-
- Reproduction*/genetics
- Male
- 3' Untranslated Regions
- MicroRNAs*/genetics
- MicroRNAs*/metabolism
- Animals
- Gene Expression Regulation, Developmental
- Female
- Transcription Factors*/genetics
- Transcription Factors*/metabolism
- Sex Characteristics
- Animals, Genetically Modified*
- Zebrafish*/genetics
- Zebrafish*/growth & development
- Zebrafish*/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- STAT5 Transcription Factor/genetics
- STAT5 Transcription Factor/metabolism
- PubMed
- 40004248 Full text @ Int. J. Mol. Sci.
Citation
Ge, S., Liu, Y., Huang, H., Yu, J., Li, X., Lin, Q., Huang, P., Mei, J. (2025) Chr23-miR-200s and Dmrt1 Control Sexually Dimorphic Trade-Off Between Reproduction and Growth in Zebrafish. International Journal of Molecular Sciences. 26:.
Abstract
In animals, a trade-off exists between reproduction and growth, which are the most fundamental traits. Males and females exhibit profound differences in reproduction and growth in fish species. However, the precise molecular mechanism governing this phenomenon is still not clear. Here, we uncovered that chr23-miR-200s and dmrt1 knockout specifically caused an impairment in reproduction and an increase in body growth in female and male zebrafish, respectively. Chr23-miR-200s and Dmrt1 directly regulate the stat5b gene by targeting its 3'UTR and promoter. The loss of stat5b completely abolished the elevated growth performance in chr23-miR-200s-KO or dmrt1-/- zebrafish. Moreover, the dmrt1 transgenic zebrafish had significantly lower body length and body weight than the control males, accompanied by a significant reduction in stat5b expression in the liver of transgenic fish. In summary, our study proposes a regulatory model elucidating the roles of chr23-miR-200s and Dmrt1 in controlling the sexually dimorphic trade-off between reproduction and growth.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping