PUBLICATION
Expanding functions of the phosphatidylinositol/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology
- Authors
- Cockcroft, S.
- ID
- ZDB-PUB-241016-11
- Date
- 2024
- Source
- Advances in Biological Regulation : 101056101056 (Journal)
- Registered Authors
- Keywords
- 14-3-3 proteins, Behavior, PA transport proteins, PITPNC1, Phosphatidic acid, Phosphatidylinositol, Type 2 diabetes
- MeSH Terms
-
- Neoplasms*/genetics
- Neoplasms*/metabolism
- Neoplasms*/pathology
- Animals
- Diabetes Mellitus, Type 2/genetics
- Diabetes Mellitus, Type 2/metabolism
- Diabetes Mellitus, Type 2/pathology
- Zebrafish/genetics
- Zebrafish/metabolism
- Brain/metabolism
- Brain/pathology
- Humans
- Phosphatidylinositols/metabolism
- PubMed
- 39406587 Full text @ Adv. Biol. Regul.
Citation
Cockcroft, S. (2024) Expanding functions of the phosphatidylinositol/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology. Advances in Biological Regulation. :101056101056.
Abstract
PITPNC1 was the last of the PITPs to be identified and has been characterized as a binding protein for phosphatidylinositol and phosphatidate. In mammals, PITPNC1 is expressed as two splice variants whilst in zebrafish is expressed from two separate genes. The two splice variants have different expression profiles with the long splice variant having a prominent role in the brain. Several physiological functions have been identified including neuronal and metabolic functions. PITPNC1 also plays a significant role in cancer and has been identified as a risk factor in type 2 diabetes. Here, we review our current understanding of PITPNC1 in cell physiology and pathology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping