PUBLICATION
Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease
- Authors
- Pang, M.Z., Li, H.X., Dai, X.Q., Wang, X.B., Liu, J.Y., Shen, Y., Xu, X., Zhong, Z.M., Wang, H., Liu, C.F., Wang, F.
- ID
- ZDB-PUB-240918-6
- Date
- 2024
- Source
- Neuroscience Bulletin 40(12): 1901-1914 (Journal)
- Registered Authors
- Liu, Chun-Feng, Wang, Fen, Wang, Han, Zhong, Zhaomin
- Keywords
- Lipid metabolism, Melatonin, Melatonin receptor 1, Parkinson’s disease, Sleep-wake disorder, Zebrafish
- MeSH Terms
-
- Melatonin*/pharmacology
- Motor Activity/drug effects
- Sleep/drug effects
- Disease Models, Animal*
- Zebrafish*
- PubMed
- 39283564 Full text @ Neurosci. Bull.
Abstract
Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease (PD). Melatonin has the potential to improve sleep-wake disorder, but its mechanism of action is still unclear. Our data showed that melatonin only improved the motor and sleep-wake behavior of a zebrafish PD model when melatonin receptor 1 was present. Thus, we explored the underlying mechanisms by applying a rotenone model. After the PD zebrafish model was induced by 10 nmol/L rotenone, the motor and sleep-wake behavior were assessed. In situ hybridization and real-time quantitative PCR were used to detect the expression of melatonin receptors and lipid-metabolism-related genes. In the PD model, we found abnormal lipid metabolism, which was reversed by melatonin. This may be one of the main pathways for improving PD sleep-wake disorder.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping