PUBLICATION

A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior

Authors
Ncube, D., Tallafuss, A., Serafin, J., Bruckner, J., Farnsworth, D.R., Miller, A.C., Eisen, J.S., Washbourne, P.
ID
ZDB-PUB-221001-1
Date
2022
Source
BMC Genomics   23: 675 (Journal)
Registered Authors
Eisen, Judith S., Farnsworth, Dylan, Miller, Adam, Tallafuss, Alexandra, Washbourne, Philip
Keywords
Neuronal identity, Neurotransmitter, Social behavior, Transcription factors
MeSH Terms
  • Acetylcholine*
  • Transcription Factors
  • Animals
  • Zebrafish*/genetics
  • Cholinergic Neurons
  • Cholinergic Agents
  • Social Behavior
  • gamma-Aminobutyric Acid
  • Neurotransmitter Agents
(all 9)
PubMed
36175871 Full text @ BMC Genomics
Abstract
An essential determinant of a neuron's functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish.
We transcriptionally profiled these neurons and discovered that they are capable of synthesizing both acetylcholine and GABA. We also established a constellation of transcription factors and neurotransmitter markers that can be used as a "transcriptomic fingerprint" to recognize a homologous neuronal population in another vertebrate.
Our results suggest that this transcriptomic fingerprint and the cholinergic-GABAergic neuronal subtype that it defines are evolutionarily conserved.
Genes / Markers
Figures
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
b1222TgTransgenic Insertion
    kca33TgTransgenic Insertion
      y321EtTransgenic Insertion
        1 - 3 of 3
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        Human Disease / Model
        No data available
        Sequence Targeting Reagents
        No data available
        Fish
        No data available
        Antibodies
        Orthology
        No data available
        Engineered Foreign Genes
        Marker Marker Type Name
        GAL4EFGGAL4
        GAL4FFEFGGAL4FF
        GFPEFGGFP
        1 - 3 of 3
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        Mapping
        No data available