PUBLICATION

Neuroprotective Effects of Estradiol plus Lithium Chloride via Anti-Apoptosis and Neurogenesis Pathway in In Vitro and In Vivo Parkinson's Disease Models

Authors
Lee, Y.S., Feng, C.W., Peng, M.Y., Chan, T.F., Chen, Y.C.
ID
ZDB-PUB-211102-8
Date
2021
Source
Parkinson's disease   2021: 3064892 (Journal)
Registered Authors
Keywords
none
MeSH Terms
none
PubMed
34721835 Full text @ Parkinsons Dis
Abstract
Few pharmaceutical agents for slowing Parkinson's disease (PD) progression existed, especially for perimenopause females. The current general medications are mostly hormone replacement therapy and may have some side effects. Therefore, there is an urgent need for a novel treatment for PD. This study examined the possibility of estradiol plus lithium chloride (LiCl), one of the metal halides used as an alternative to salt. We showed that the combination of LiCl and estradiol could enhance neurogenesis proteins GAP-43 and N-myc in the human neuronal-like cells. We also further confirmed the neurogenesis activity in zebrafish. LiCl and LiCl plus estradiol could enhance 6-OHDA-induced upregulation of TGase-2b and Rho A mRNA expression. Besides, LiCl plus estradiol showed a synergic effect in anti-apoptotic activity. LiCl plus estradiol protected SH-SY5Y cells and zebrafish against 6-OHDA-induced damage on neurons than LiCl or estradiol alone groups via p-P38, p-Akt, Bcl-2, and caspase-3 cascade. The potential for developing this combination as a candidate treatment for PD is discussed.
Genes / Markers
Figures
Figure Gallery (8 images)
Show all Figures
Expression
No data available
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
No data available
Fish
No data available
Antibodies
Name Type Antigen Genes Isotypes Host Organism
Ab1-mapk14polyclonal
    Rabbit
    Ab2-aktpolyclonal
      Rabbit
      Ab2-mycnpolyclonal
        IgGRabbit
        Ab3-aktpolyclonal
          Rabbit
          Ab3-thmonoclonalIgG1Mouse
          Ab7-mapkpolyclonal
            Rabbit
            Ab13-mapkpolyclonal
              Rabbit
              Ab13-mapk14polyclonal
                Rabbit
                1 - 8 of 8
                Show
                Orthology
                No data available
                Engineered Foreign Genes
                No data available
                Mapping
                No data available