PUBLICATION

Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development

Authors
Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M.
ID
ZDB-PUB-210606-3
Date
2021
Source
Developmental Biology   477: 205-218 (Journal)
Registered Authors
Parichy, David M.
Keywords
Growth, Patterning, Postembryonic development, Scales, Squamation, Thyroid hormone, Zebrafish
MeSH Terms
  • Morphogenesis
  • Animal Scales/growth & development
  • Zebrafish/growth & development*
  • Animals
  • Body Patterning/physiology
  • Skin/growth & development*
  • Thyroid Hormones/physiology*
(all 7)
PubMed
34089732 Full text @ Dev. Biol.
Abstract
Thyroid hormone is a key regulator of post-embryonic vertebrate development. Skin is a biomedically important thyroid hormone target organ, but the cellular and molecular mechanisms underlying skin pathologies associated with thyroid dysfunction remain obscure. The transparent skin of zebrafish is an accessible model system for studying vertebrate skin development. During post-embryonic development of the zebrafish, scales emerge in the skin from a hexagonally patterned array of dermal papillae, like other vertebrate skin appendages such as feathers and hair follicles. We show here that thyroid hormone regulates the rate of post-embryonic dermal development through interaction with nuclear hormone receptors. This couples skin development with body growth to generate a well ordered array of correctly proportioned scales. This work extends our knowledge of thyroid hormone actions on skin by providing in-vivo evidence that thyroid hormone regulates multiple aspects of dermal development.
Genes / Markers
Figures
Figure Gallery (21 images) / 3
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
No data available
Sequence Targeting Reagents
Fish
Antibodies
Orthology
No data available
Engineered Foreign Genes
Marker Marker Type Name
CeruleanEFGCerulean
EGFPEFGEGFP
mCherryEFGmCherry
NTREFGNTR
TomatoEFGTomato
VenusEFGVenus
YFPEFGYFP
1 - 7 of 7
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Mapping
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Citation
Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M. (2021) Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development. Developmental Biology. 477:205-218.